miR33 Inhibition Overcomes Deleterious Effects of Diabetes Mellitus on Atherosclerosis Plaque Regression in Mice
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چکیده
منابع مشابه
miR33 inhibition overcomes deleterious effects of diabetes mellitus on atherosclerosis plaque regression in mice.
RATIONALE Diabetes mellitus increases cardiovascular disease risk in humans and remains elevated despite cholesterol-lowering therapy with statins. Consistent with this, in mouse models, diabetes mellitus impairs atherosclerosis plaque regression after aggressive cholesterol lowering. MicroRNA 33 (miR33) is a key negative regulator of the reverse cholesterol transport factors, ATP-binding casse...
متن کاملmir33 Inhibition Overcomes Deleterious Effects of Diabetes on Atherosclerosis Plaque Regression in Mice
1Leon H. Charney Division of Cardiology and Marc and Ruti Bell Program in Vascular Biology, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA; 2Department of Microbiology, New York University School of Medicine, New York, New York, NY 10016, USA; 3Regulus Therapeutics, San Diego, California, USA; 4Division of Molecular Medicine, Department of Medicine, Colu...
متن کاملDiabetes Mellitus Adversely Affects Macrophages During Atherosclerotic Plaque Regression in Mice
RESEARCH DESIGN AND METHODS—Reversa mice are LDL receptor–deficient mice that develop atherosclerosis. Their elevated plasma LDL levels are lowered after conditional knockout of the gene encoding microsomal triglyceride transfer protein. We examined the morphologic and molecular changes in atherosclerotic plaques in control and streptozotocin-diabetic Reversa mice after LDL lowering. Bone marro...
متن کاملDiabetes Adversely Affects Macrophages During Atherosclerotic Plaque Regression in Mice
OBJECTIVE Patients with diabetes have increased cardiovascular risk. Atherosclerosis in these patients is often associated with increased plaque macrophages and dyslipidemia. We hypothesized that diabetic atherosclerosis involves processes that impair favorable effects of lipid reduction on plaque macrophages. RESEARCH DESIGN AND METHODS Reversa mice are LDL receptor-deficient mice that devel...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2014
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.115.304164